前列环素（PGI2）、前列腺素E1和D2对不同物种血小板聚集作用的比较。

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species.

作者信息

Whittle B J, Moncada S, Vane J R

出版信息

Prostaglandins. 1978 Sep;16(3):373-88. doi: 10.1016/0090-6980(78)90216-2.

Abstract

The activity of prostacyclin (PGI2), PGE1 or PGD2 as inhibitors of platelet aggregation in plasma from human, dog, rabbit, rat, sheep and horse was investigated. Prostacyclin was the most potent inhibitor in all species. PGD2 was a weak inhibitor in dog, rabbit and rat plasma whereas PGE1 and prostacyclin were highly active. Theophylline or dipyridamole potentiated the inhibition of human platelet aggregation by prostacyclin, PGE1 or PGD2. Compound N-0164 abolished the inhibition by PGD2 of human platelet aggregation but did not inhibit the effects of PGE1 or prostacyclin. The results suggest that prostacyclin and PGE1 act on similar sites on platelets which are distinct from those for PGD2.

摘要

研究了前列环素（PGI2）、前列腺素E1（PGE1）或前列腺素D2（PGD2）作为人、狗、兔、大鼠、绵羊和马血浆中血小板聚集抑制剂的活性。前列环素在所有物种中都是最有效的抑制剂。PGD2在狗、兔和大鼠血浆中是一种弱抑制剂，而PGE1和前列环素具有高度活性。茶碱或双嘧达莫增强了前列环素、PGE1或PGD2对人血小板聚集的抑制作用。化合物N-0164消除了PGD2对人血小板聚集的抑制作用，但不抑制PGE1或前列环素的作用。结果表明，前列环素和PGE1作用于血小板上与PGD2不同的相似位点。