van Zyl J A, Muller M A, van Niekerk W A
S Afr Med J. 1980 Oct 11;58(15):591-8.
Thirty-six women with endometriosis externa were treated with danazol (Ladogar; Winthrop Laboratories, Division of Sterling Drug (SA) (Pty) Ltd) for 6 months. In 15 cases treatment was combined with conservative surgery. Of these patients 34 presented with the complaint of infertility. The results were evaluated by means of repeat laparoscopy and biopsy. Of 21 patients treated with danazol only 9 (42,9%) were completely healed, and 10 (47,6%) showed a good response, giving an overall response of 90,5% and a corrected conception rate of 52,9%. Of the 15 patients who were treated with danazol combined with conservative surgery, 9 (60%) have completely healed, and 3 had a recurrence of endometriosis. This group had a corrected pregnancy rate of 30,8%. The majority of conceptions (61,5%) occurred during the first 6 months after treatment, 92,3% within the 1st year and 1 a year after conclusion of treatment. Of the 13 conceptions, 11 were successful, 1 ended in an abortion and 1 in an ectopic pregnancy, and 1 small-for-gestational-age infant was delivered.
36例外在性子宫内膜异位症女性患者接受了达那唑（Ladogar；斯特林药物（南非）有限公司温思罗普实验室生产）治疗6个月。其中15例患者的治疗结合了保守手术。这些患者中有34例主诉不孕。通过重复腹腔镜检查和活检对结果进行评估。在仅接受达那唑治疗的21例患者中，9例（42.9%）完全治愈，10例（47.6%）反应良好，总体有效率为90.5%，校正受孕率为52.9%。在接受达那唑联合保守手术治疗的15例患者中，9例（60%）完全治愈，3例子宫内膜异位症复发。该组校正妊娠率为30.8%。大多数妊娠（61.5%）发生在治疗后的前6个月内，92.3%发生在第1年内，1例发生在治疗结束1年后。在13例妊娠中，11例成功，1例流产，1例异位妊娠，1例分娩出小于孕周的婴儿。
