Mahmood F, Mahmood N H, Holms W H
Zentralbl Bakteriol A. 1980 Mar;246(3):329-35.
Quinolones, a large group of substituted heterocyclic compounds synthesized by ICI (U.K.), showed antibacterial activity both in vivo and in vitro studies. In the present work an attempt was made to evaluate their antibacterial activity in relation to their chemical structure. Active compounds possess carboxylic and nitroside groups. Regarding the pattern of growth inhibition quinolone with carboxylic side group showed a different behaviour than quinolone possessing nitro side group.
喹诺酮类是由英国帝国化学工业公司合成的一大类取代杂环化合物，在体内和体外研究中均显示出抗菌活性。在本研究中，我们试图评估它们的抗菌活性与其化学结构之间的关系。活性化合物含有羧基和亚硝基。关于生长抑制模式，带有羧基侧链的喹诺酮类表现出与带有硝基侧链的喹诺酮类不同的行为。
