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Synthesis and antibacterial property of quinolines with potent DNA gyrase activity.

作者信息

Ramesh Ekambaram, Manian Rathna Durga R S, Raghunathan Ragavachary, Sainath Shilpakala, Raghunathan Malathi

机构信息

Department of Organic Chemistry, Guindy Campus, University of Madras, Chennai 600025, India.

出版信息

Bioorg Med Chem. 2009 Jan 15;17(2):660-6. doi: 10.1016/j.bmc.2008.11.058. Epub 2008 Dec 3.

DOI:10.1016/j.bmc.2008.11.058
PMID:19097914
Abstract

Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against microorganisms of which one of them 7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5 mg/mL against Escherichia coli.

摘要

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