Jacks T M, Schleim K D, Judith F R, Miller B M
Antimicrob Agents Chemother. 1980 Sep;18(3):397-402. doi: 10.1128/AAC.18.3.397.
Cephamycin C is a beta-lactam antibiotic that has broad gram-negative activity and is resistant to degradation by beta-lactamases and safe for use in animals. In colostrum-fed calves infected with Escherichia coli strain B44, cephamycin C administered by gavage at 31.3 to 1,000 mg per calf (0.75 to 24 mg/kg) twice a day for 6 days starting at 20 h post-inoculation eliminated the diarrhea and reduced the mortality from 90% in infected, nonmedicated calves to 14% in infected, medicated calves (P < 0.01). Comparable results were obtained with a shorter treatment regimen (30 mg of cephamycin C per calf [0.71 mg/kg] twice a day for 3 days). In colostrum-fed piglets infected with E. coli strain P155 and housed in cages, cephamycin C administered prophylactically by gavage at 12.5 mg per piglet (10.4 mg/kg) twice a day for 4 days completely prevented both diarrhea and mortality, whereas nonmedicated piglets had 100% diarrhea and all died. When eight doses of cephamycin C were given therapeutically starting at 6 h post-inoculation, mortality was reduced from 79 to 23% (P < 0.02), and diarrhea was eliminated in the surviving medicated piglets by 4 days post-inoculation. In infected suckling piglets, cephamycin C administered therapeutically by gavage at 12.5 mg per piglet twice a day for 3 days starting at 6 h post-inoculation, diarrhea and mortality were reduced (P < 0.05): infected, nonmedicated piglets had 87% diarrhea and 75% mortality, whereas infected, medicated piglets had 25% diarrhea and 31% mortality. All surviving medicated piglets had solid feces by 2 days post-inoculation. Thus, cephamycin C was highly effective in restoring the calves and piglets to good health by eliminating diarrhea and reducing mortality.
头孢西丁C是一种β-内酰胺类抗生素，具有广泛的革兰氏阴性菌活性，对β-内酰胺酶降解具有抗性，且对动物使用安全。在感染大肠杆菌B44菌株的初乳喂养犊牛中，从接种后20小时开始，以每头犊牛31.3至1000毫克（0.75至24毫克/千克）的剂量通过灌胃给予头孢西丁C，每天两次，持续6天，消除了腹泻，并将死亡率从未用药的感染犊牛的90%降至用药的感染犊牛的14%（P<0.01）。采用较短的治疗方案（每头犊牛30毫克头孢西丁C[0.71毫克/千克]，每天两次，持续3天）也获得了类似的结果。在感染大肠杆菌P155菌株并饲养在笼中的初乳喂养仔猪中，以每头仔猪12.5毫克（10.4毫克/千克）的剂量通过灌胃预防性给予头孢西丁C，每天两次，持续4天，完全预防了腹泻和死亡，而未用药的仔猪腹泻率为100%且全部死亡。当从接种后6小时开始给予八剂头孢西丁C进行治疗时，死亡率从79%降至23%（P<0.02），并且在接种后4天时，存活的用药仔猪的腹泻症状消除。在感染的哺乳仔猪中，从接种后6小时开始，以每头仔猪12.5毫克的剂量通过灌胃每天两次给予头孢西丁C，持续3天，腹泻和死亡率降低（P<0.05）：未用药的感染仔猪腹泻率为87%，死亡率为75%，而用药的感染仔猪腹泻率为25%，死亡率为31%。所有存活的用药仔猪在接种后2天时粪便成形。因此，头孢西丁C通过消除腹泻和降低死亡率，在使犊牛和仔猪恢复健康方面非常有效。
