Jacks T M, Welter C J, Fitzgerald G R, Miller B M
Antimicrob Agents Chemother. 1981 Apr;19(4):562-6. doi: 10.1128/AAC.19.4.562.
Weanling pigs in groups of 12 were infected orally with Salmonella choleraesuis and were treated intramuscularly with doses of cephamycin C ranging from 12.5 to 337.5 mg twice daily for 10 days beginning 1 day postinoculation. Pigs in two other infected groups either received 300 mg of tetracycline orally on a similar schedule or served as nonmedicated controls. Optimal responses to cephamycin C were achieved at a twice daily dose of 112.5 mg. With this regimen, the febrile response was significantly reduced on day 2 and eliminated by day 5 postinfection, and the shedding of Salmonella spp. in feces was eliminated by day 5 postinfection; essentially, no lesions were found in the gastrointestinal tract at necropsy (day 26 postinfection). There was no mortality among recipients of the 112.5-mg dose; diarrhea was present on only 2% of the observation days. In contrast, 83% of the infected, nonmedicated pigs and 25% of the tetracycline-medicated pigs died, and diarrhea was present in these groups on 63 and 54% of the observation days, respectively. The striking benefits of cephamycin C treatment was achieved without adverse reactions. The weight gain and feed efficiency of the infected pigs treated with the 112.5-mg dose of cephamycin C and the noninfected, nonmedicated control pigs were equivalent.
将12头一组的断奶仔猪经口感染猪霍乱沙门氏菌，并在接种后1天开始，每天两次肌肉注射剂量为12.5至337.5毫克的头孢霉素C，持续10天。另外两组感染的仔猪，一组按类似方案口服300毫克四环素，另一组作为未用药对照组。头孢霉素C的最佳反应是每天两次剂量为112.5毫克时实现的。采用该方案，感染后第2天发热反应显著降低，第5天消除，感染后第5天粪便中沙门氏菌的排出消除；本质上，尸检时（感染后第26天）在胃肠道未发现病变。接受112.5毫克剂量的仔猪没有死亡；腹泻仅出现在2%的观察日。相比之下，83%的感染未用药仔猪和25%的四环素用药仔猪死亡，腹泻分别出现在这些组63%和54%的观察日。头孢霉素C治疗有显著益处且无不良反应。接受112.5毫克剂量头孢霉素C治疗的感染仔猪与未感染未用药对照仔猪的体重增加和饲料效率相当。
