Freeman R D
Exp Brain Res. 1978 Sep 15;33(1):51-63. doi: 10.1007/BF00238794.
It is known that kittens reared in ways that restrict movement while visual stimulation is received exhibit deficits in visually guided behavior. Presumably, the behavioral dysfunction is due to a lack of sensorimotor coordination during visual exposure. The current investigation was undertaken to study this effect both physiologically and behaviorally. Two groups of kittens were normally reared until they were nearly 4 weeks old. They were then placed in a darkroom and exposed daily for 1--2 hours while one eye was occluded. On alternate days, alternate eyes were covered. One group was restrained in a body cast while a given eye was exposed, but the kittens were free to move about while the other eye received visual experience. A second control group was alternately occluded, but freely mobile during all exposures. An additional cat was also unrestrained during daily rearing periods and neither eye was ever occluded. Behavioral tests showed clear deficits when the "passive" eye of the restrained-unrestrained group was used. Deficiencies were found in visually guided paw placing, pursuit eye movements, and jumping behavior to a platform. Responses of single cells were studied in area 17 of the visual cortex. Ocular dominance distributions showed marked reductions in binocularity for alternated occluder cats. The eye that had received exposure while animals were active in the restrained-unrestrained group also tended to predominate but the difference was not statistically significant.
众所周知，在接受视觉刺激时以限制运动的方式饲养的小猫，在视觉引导行为方面表现出缺陷。据推测，行为功能障碍是由于视觉暴露期间缺乏感觉运动协调。当前的研究旨在从生理和行为两方面研究这种影响。两组小猫正常饲养至近4周龄。然后将它们置于暗室中，每天暴露1至2小时，同时一只眼睛被遮挡。隔天交替遮挡不同的眼睛。一组小猫在暴露一只眼睛时被固定在石膏模型中，但在另一只眼睛接受视觉体验时小猫可以自由活动。第二组对照组也交替进行遮挡，但在所有暴露期间都可以自由活动。另外还有一只猫在日常饲养期间不受限制，且两只眼睛都从未被遮挡。行为测试表明，当使用限制-非限制组的“被动”眼时，会出现明显的缺陷。在视觉引导的爪子放置、追踪眼球运动和跳上平台的行为中都发现了缺陷。对视觉皮层17区的单细胞反应进行了研究。双眼优势分布显示，交替遮挡组的双眼性显著降低。在限制-非限制组中，当动物处于活动状态时接受暴露的眼睛也往往占主导地位，但差异无统计学意义。
