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戊巴比妥、水合氯醛、乙醚和原藜芦碱对大鼠皮质突触体中突触小泡分布的影响。

The effect of pentobarbital, chloralhydrate, ether and protoveratrine on the distribution of synaptic vesicles in rat cortical synaptosomes.

作者信息

Hajós F, Csillag A, Kálmán M

出版信息

Exp Brain Res. 1978 Sep 15;33(1):91-99. doi: 10.1007/BF00238797.

DOI:10.1007/BF00238797
PMID:700002
Abstract

Rat cortical synaptosomes were incubated in a saline medium. On the addition of pentobarbital, chloralhydrate, ether and protoveratrine a redistribution of synaptic vesicles was revealed by electron microscopy. The anaesthetics decreased the number of synaptic vesicles attached to the presynaptic membrane while protoveratrine increased them. It is assumed that these agents affect the mechanism of vesicle reformation from the synaptosomal membrane and/or vesicle migration towards the synaptic cleft.

摘要

将大鼠大脑皮层突触体置于盐溶液培养基中进行孵育。加入戊巴比妥、水合氯醛、乙醚和原藜芦碱后，通过电子显微镜观察到突触小泡出现了重新分布。这些麻醉剂减少了附着于突触前膜的突触小泡数量，而原藜芦碱则使其增加。据推测，这些药物影响了突触体膜形成小泡的机制和/或小泡向突触间隙的迁移。

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引用本文的文献

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