一种用于研究动脉粥样硬化初始事件的模型系统。
A model system for studying initial events in atherosclerosis.
作者信息
Silver M J, Sedar A W, Nissenbaum M, Ingerman C, Smith J B
出版信息
Artery. 1980;8(1):80-4.
PMID:7000044
Abstract
A model system has been developed which employs the central artery of the rabbit ear, and allows for the study of 1) ultra-structural changes in the arterial endothelium and 2) formation and release of prostacyclin and thromboxane from the arteries in situ. Use of the model should be helpful in evaluating the initial events in atherosclerosis. Both prostacyclin and thromboxane (detected by radioimmunoassay) were formed by arteries in situ in response to infusion of sodium arachidonate.
摘要
已经开发出一种模型系统，该系统采用兔耳中央动脉，可用于研究：1）动脉内皮的超微结构变化；2）原位动脉中前列环素和血栓素的形成与释放。使用该模型有助于评估动脉粥样硬化的初始事件。通过放射免疫测定法检测到，原位动脉在输注花生四烯酸钠后会形成前列环素和血栓素。
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