Rozinova V N
Arkh Patol. 1980;42(9):75-82.
The review presents information on proliferation of smooth muscle cells (SMC) of the arterial wall as the key moment in atherogenesis. Some factors influencing SMC proliferation as well as some aspects of SMC biology the knowledge of which is necessary for better understanding of some current hypotheses of atherosclerosis are considered. SMC proliferation has been recognized as the main cause of atherosclerosis relatively recently. Each of the original theories or hypotheses of the atherosclerosis pathogenesis under consideration is focused on different factors underlying SMC proliferation and deals with the problems the resolution of which helps better understanding of the causes and genesis of this disease.
这篇综述介绍了动脉壁平滑肌细胞(SMC)增殖这一动脉粥样硬化发生过程中的关键环节。文中考虑了一些影响SMC增殖的因素以及SMC生物学的某些方面,了解这些知识对于更好地理解当前一些动脉粥样硬化假说十分必要。SMC增殖直到最近才被确认为动脉粥样硬化的主要原因。所考虑的动脉粥样硬化发病机制的每一个原始理论或假说都聚焦于SMC增殖背后的不同因素,并探讨了相关问题,解决这些问题有助于更好地理解该疾病的病因和发病过程。