• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Naloxone modulates the perception of itch in man.纳洛酮可调节人类的瘙痒感知。
Br J Clin Pharmacol. 1980 Aug;10(2):180-3. doi: 10.1111/j.1365-2125.1980.tb01742.x.
2
Relief of intractable pruritus with naloxone.
Arch Dermatol. 1979 Nov;115(11):1366-7.
3
The pruritus of cholestasis is relieved by an opiate antagonist: is this pruritus a centrally mediated phenomenon?胆汁淤积性瘙痒可通过阿片类拮抗剂缓解：这种瘙痒是中枢介导的现象吗？
Hepatology. 1996 May;23(5):1280-2. doi: 10.1053/jhep.1996.v23.ajhep0231280.
4
Naloxone, itch, asthma, urticaria, and angioedema.纳洛酮、瘙痒、哮喘、荨麻疹和血管性水肿。
Ann Intern Med. 1982 Nov;97(5):788-9. doi: 10.7326/0003-4819-97-5-788_3.
5
[Cholestatic pruritus--pathophysiology and therapy with special reference to treatment with 5-hydroxytryptamine subtype 3 receptor antagonists].[胆汁淤积性瘙痒——病理生理学与治疗，特别提及5-羟色胺3型受体拮抗剂的治疗]
Z Gastroenterol. 1995 May;33(5):265-74.
6
Pathogenesis and management of pruritus in cholestatic liver disease.胆汁淤积性肝病瘙痒的发病机制与治疗。
J Gastroenterol Hepatol. 2012 Jul;27(7):1150-8. doi: 10.1111/j.1440-1746.2012.07109.x.
7
Opioid antagonist for pruritus of cholestasis unmasking bony metastases.用于胆汁淤积性瘙痒且揭示骨转移的阿片类拮抗剂。
Acta Derm Venereol. 2009;89(1):90. doi: 10.2340/00015555-0538.
8
The influence of the opiate antagonist naloxone on experimental pruritus.阿片类拮抗剂纳洛酮对实验性瘙痒的影响。
Acta Derm Venereol. 1984;64(1):73-5.
9
Pilot study of the use of naltrexone to treat the severe pruritus of cholestatic liver disease.纳曲酮用于治疗胆汁淤积性肝病严重瘙痒的初步研究。
Am J Gastroenterol. 1996 May;91(5):1022-3.
10
Low dose naloxone for pruritus in systemic sclerosis: Case series and literature review.低剂量纳洛酮治疗系统性硬化症瘙痒：病例系列及文献复习。
Medicine (Baltimore). 2022 Jan 28;101(4):e28653. doi: 10.1097/MD.0000000000028653.

引用本文的文献

1
Effect of Intradermal Morphine on Histaminergic and Non-Histaminergic Itch: A Randomised, Single-Blinded, Human Study.皮内注射吗啡对组胺能和非组胺能瘙痒的影响：一项随机、单盲人体研究。
Exp Dermatol. 2025 Aug;34(8):e70149. doi: 10.1111/exd.70149.
2
Cholestatic Pruritus Treatments in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Systematic Literature Review.原发性胆汁性胆管炎和原发性硬化性胆管炎的胆汁淤积性瘙痒治疗：系统文献回顾。
Dig Dis Sci. 2023 Jun;68(6):2710-2730. doi: 10.1007/s10620-023-07862-z. Epub 2023 Mar 18.
3
Cholestatic pruritus: Emerging mechanisms and therapeutics.胆汁淤积性瘙痒：新出现的发病机制和治疗方法。
J Am Acad Dermatol. 2019 Dec;81(6):1371-1378. doi: 10.1016/j.jaad.2019.04.035. Epub 2019 Apr 19.
4
Clinical Efficacy and Safety of Naltrexone Combination Therapy in Older Patients with Severe Pruritus.纳曲酮联合疗法治疗老年重度瘙痒患者的临床疗效与安全性
Ann Dermatol. 2016 Apr;28(2):159-63. doi: 10.5021/ad.2016.28.2.159. Epub 2016 Mar 31.
5
Pathogenesis and treatment of pruritus in cholestasis.胆汁淤积性瘙痒的发病机制与治疗
Drugs. 2008;68(15):2163-82. doi: 10.2165/00003495-200868150-00006.
6
Hepatic disorders. Features and appropriate management.肝脏疾病。特征及恰当的管理。
Drugs. 1995 Jan;49(1):83-102. doi: 10.2165/00003495-199549010-00007.
7
Intraspinal opiates and itching: a new reflex?脊髓内阿片类药物与瘙痒：一种新的反射？
Br Med J (Clin Res Ed). 1982 Apr 3;284(6321):1015-6. doi: 10.1136/bmj.284.6321.1015.
8
Naloxone: new therapeutic roles.
Can Anaesth Soc J. 1984 May;31(3 Pt 1):272-8. doi: 10.1007/BF03007888.
9
Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK-33-824, beta-endorphin and morphine.脑啡肽类似物FK-33-824、β-内啡肽和吗啡对组胺诱导的人皮肤瘙痒和潮红反应的增强作用。
Arch Dermatol Res. 1982;274(1-2):29-37. doi: 10.1007/BF00510355.
10
The new dermatology.新皮肤病学
BMJ. 1990 Feb 17;300(6722):413-4. doi: 10.1136/bmj.300.6722.413.

本文引用的文献

1
Touch, pain and tickling: an electro-physiological investigation on cutaneous sensory nerves.触觉、痛觉与瘙痒觉：皮肤感觉神经的电生理研究
J Physiol. 1939 Feb 14;95(1):1-28. doi: 10.1113/jphysiol.1939.sp003707.
2
Observations on the scratch-reflex in the spinal dog.对脊髓狗搔抓反射的观察。
J Physiol. 1906 Mar 13;34(1-2):1-50. doi: 10.1113/jphysiol.1906.sp001139.
3
Neural mechanisms involved in itch, itchy skin, and tickle sensations.与瘙痒、皮肤瘙痒和痒感相关的神经机制。
J Clin Invest. 1951 Jan;30(1):37-49. doi: 10.1172/JCI102414.
4
Morphine tolerance in hepatic cirrhosis.肝硬化中的吗啡耐受性。
Gastroenterology. 1961 Mar;40:389-96.
5
The powerful placebo.强效安慰剂
J Am Med Assoc. 1955 Dec 24;159(17):1602-6. doi: 10.1001/jama.1955.02960340022006.
6
Drug interaction in the field of analgesic drugs.镇痛药领域的药物相互作用。
Proc R Soc Med. 1965 Nov;58(11 Part 2):978-83. doi: 10.1177/003591576505811P207.
7
Graphic representation of pain.疼痛的图形表示。
Pain. 1976 Jun;2(2):175-84.
8
The narcotic antagonist naloxone enhances clinical pain.麻醉拮抗剂纳洛酮会加剧临床疼痛。
Nature. 1978 Apr 27;272(5656):826-7. doi: 10.1038/272826a0.
9
Naloxone alters pain perception and somatosensory evoked potentials in normal subjects.纳洛酮可改变正常受试者的疼痛感知和体感诱发电位。
Nature. 1977 Dec 15;270(5638):620-22. doi: 10.1038/270620a0.
10
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.对可能与疼痛和镇痛相关的肽通路的免疫组织化学分析：脑啡肽和P物质。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3081-5. doi: 10.1073/pnas.74.7.3081.

Naloxone modulates the perception of itch in man.

作者信息

Summerfield J A

出版信息

Br J Clin Pharmacol. 1980 Aug;10(2):180-3. doi: 10.1111/j.1365-2125.1980.tb01742.x.

DOI:10.1111/j.1365-2125.1980.tb01742.x
PMID:7000110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1430035/
Abstract
摘要