Denekamp J
Br J Cancer Suppl. 1980 Apr;4:56-63.
The different assays available for measuring the response of undisturbed tumours in situ after therapy are reviewed. These are: animal survival time, regression rate of tumours, regrowth delay, local tumour control and loss of incorporated radioactivity. The relative advantages and disadvantages of each assay are reviewed in terms of cost-effectiveness and the relevance of the data they yield. For comparisons of different treatment modalities any single assay seems adequate provided a dose-response relationship can be demonstrated. The assay of choice will depend upon: the dose-range to be investigated, the amount of prior information that is required and the skills and apparatus that are available. No single assay is clearly best, but survival time and regression rate studies probably yield the least valuable information. If the main question is the absolute number of cells surviving a particular treatment, or the mechanisms leading to a given response, no single assay will yield as much information as a combination of several in situ techniques, together with excision assays. For clinically oriented questions, however, a single assay may be adequate. The choice of an appropriate tumour model is the most important factor in determining the relevance of the data obtained from mice for man.
本文综述了可用于测量治疗后原位未受干扰肿瘤反应的不同检测方法。这些方法包括：动物存活时间、肿瘤消退率、再生长延迟、局部肿瘤控制以及掺入放射性的丧失。从成本效益以及它们所产生数据的相关性方面，对每种检测方法的相对优缺点进行了综述。对于不同治疗方式的比较，只要能证明剂量反应关系，任何一种单一检测方法似乎都足够。检测方法的选择将取决于：要研究的剂量范围、所需的先验信息量以及可用的技术和仪器。没有一种单一检测方法明显是最好的，但存活时间和消退率研究可能产生的有价值信息最少。如果主要问题是特定治疗后存活的细胞绝对数量，或者导致特定反应的机制，那么没有一种单一检测方法能像几种原位技术与切除检测相结合那样提供如此多的信息。然而，对于临床导向的问题，一种单一检测方法可能就足够了。选择合适的肿瘤模型是确定从小鼠获得的数据对人类的相关性的最重要因素。
