蝮蛇毒所致大鼠局灶性系膜增生性肾小球肾炎：抗血小板药物的作用
Focal mesangial proliferative glomerulonephritis in the rat caused by Habu venom: the effect of antiplatelet agents.
作者信息
Cattell V, Mehotra A
出版信息
Br J Exp Pathol. 1980 Jun;61(3):310-4.
Abstract
The effects of the antiplatelet agents aspirin (ASA), dipyridamole (DP) and prostacyclin (PGI2) on glomerulonephritis following Habu snake venom have been investigated. ASA greatly increases glomerular damage and PGI2 inhibits glomerular damage. DP suppresses glomerular proliferation. The results extend previous studies on platelet activity in this model and provide evidence that (1) glomerular injury involves a platelet/endothelial reaction and (2) glomerular proliferation is affected by an antiplatelet drug.
摘要
已对抗血小板药物阿司匹林（ASA）、双嘧达莫（DP）和前列环素（PGI2）对哈布蛇毒诱导的肾小球肾炎的影响进行了研究。ASA显著增加肾小球损伤，而PGI2抑制肾小球损伤。DP抑制肾小球增殖。这些结果扩展了此前对该模型中血小板活性的研究，并提供了证据表明：（1）肾小球损伤涉及血小板/内皮反应；（2）肾小球增殖受抗血小板药物影响。
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Focal mesangial proliferative glomerulonephritis in the rat caused by Habu venom: the effect of antiplatelet agents.蝮蛇毒所致大鼠局灶性系膜增生性肾小球肾炎：抗血小板药物的作用
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引用本文的文献
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Platelet-complement interactions in mesangial proliferative nephritis in the rat.大鼠系膜增生性肾炎中的血小板-补体相互作用
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本文引用的文献
1
Action of Trimeresurus flavoviridis venom and the partially purified hemorrhagic principles on animal cells cultivated in vitro.竹叶青蛇毒及其部分纯化的出血因子对体外培养动物细胞的作用。
Toxicon. 1966 Nov;4(3):183-90. doi: 10.1016/0041-0101(66)90048-1.
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Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake venom. A morphologic study.蝮蛇毒所致大鼠局灶性系膜增生性肾小球肾炎。一项形态学研究。
Am J Pathol. 1977 Jun;87(3):511-24.
3
4
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.同型胱氨酸诱导的动脉硬化。内皮细胞损伤和血小板反应在其发生过程中的作用。
J Clin Invest. 1976 Sep;58(3):731-41. doi: 10.1172/JCI108520.
5
A comparison of the effects of aspirin and dipyridamole on platelet aggregation in vivo and ex vivo.阿司匹林和双嘧达莫对体内及体外血小板聚集作用的比较。
Thromb Res. 1978 Sep;13(3):517-29. doi: 10.1016/0049-3848(78)90137-8.
6
The action mechanism of the purified platelet aggregation principle of Trimeresurus mucrosquamatus venom.尖吻蝮蛇毒纯化血小板聚集素的作用机制。
Thromb Haemost. 1979 May 25;41(3):475-90.
7
Focal mesangial proliferative glomerulonephritis in the rat caused by Habu snake venom: the role of platelets.蝮蛇毒所致大鼠局灶性系膜增生性肾小球肾炎：血小板的作用
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Thromb Res. 1979 Feb-Mar;14(2-3):311-21. doi: 10.1016/0049-3848(79)90240-8.
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Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy.前列环素（PGI2）与血栓素A2在体内的相互作用。阿司匹林的调节作用及其与抗血栓治疗的关系。
Thromb Res. 1978 Sep;13(3):489-500. doi: 10.1016/0049-3848(78)90134-2.
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