阿替洛尔与氯噻酮治疗南非黑人高血压的试验。
Trial of atenolol and chlorthalidone for hypertension in black South Africans.
作者信息
Seedat Y K
出版信息
Br Med J. 1980 Nov 8;281(6250):1241-3. doi: 10.1136/bmj.281.6250.1241.
Abstract
Twenty-four black patients (Zulus) with hypertension participated in a double-blind, placebo-controlled cross-over trial of the efficacy of a beta-blocking agent (atenolol) 100 mg once daily as compared with chlorthalidone 25 mg once daily. The two drugs were also given combined at these doses and the effects compared with those of the drugs given alone. Atenolol as sole treatment had no appreciable effect on blood pressure as compared with placebo. Chlorthalidone produced a small decrease, but this was not statistically significant. Combining the two drugs, however, produced a significant reduction in blood pressure (mean lying blood pressure p < 0.001; mean standing blood pressure p < 0.0002). These findings suggest that beta-blockers should not be regarded as baseline treatment of hypertension in blacks.
摘要
24名患有高血压的黑人患者（祖鲁人）参与了一项双盲、安慰剂对照的交叉试验，该试验旨在比较每日一次服用100毫克β受体阻滞剂（阿替洛尔）与每日一次服用25毫克氯噻酮的疗效。这两种药物也以这些剂量联合使用，并将其效果与单独使用药物的效果进行比较。与安慰剂相比，单独使用阿替洛尔对血压没有明显影响。氯噻酮使血压略有下降，但这在统计学上并不显著。然而，将这两种药物联合使用可使血压显著降低（平均卧位血压p<0.001；平均立位血压p<0.0002）。这些发现表明，β受体阻滞剂不应被视为黑人高血压的基础治疗药物。
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