阿替洛尔、甲基多巴和氯噻酮用于治疗中度高血压。
Atenolol, methyldopa, and chlorthalidone in moderate hypertension.
作者信息
Webster J, Jeffers T A, Galloway D B, Petrie J C, Barker N P
出版信息
Br Med J. 1977 Jan 8;1(6053):76-8. doi: 10.1136/bmj.1.6053.76.
Combined treatment with low doses of different drugs is widely used for moderate hypertension. The effects of atenolol and methyldopa at two dose levels and in combination at the lower doses were studied in patients with moderate hypertension on continuous treatment with moderate hypertension on continuous treatment with chlorthalidone. The mean reduction in standing blood pressures obtained with atenolol 150 and 300 mg/day was about 27/17 mm Hg and with methyldopa 750 and 1500 mg/day about 28/14 mm Hg. Combined treatment with atenolol 150 mg/day and methyldopa 750 mg/day for four weeks resulted in a reduction of 38/25 mm Hg. No difference was observed between the two doses of methyldopa. The lower dose of atenolol was better than the lower dose of methyldopa in reducing lying and standing diastolic blood pressures. These findings show that in patients on continuous treatment with chlorthalidone the addition of atenolol alone or methyldopa alone or of atenolol and methyldopa in combination is effective in the treatment of moderate hypertension.
低剂量不同药物联合治疗广泛用于中度高血压。在持续服用氯噻酮治疗中度高血压的患者中，研究了阿替洛尔和甲基多巴两种剂量水平以及低剂量联合用药的效果。阿替洛尔每日150毫克和300毫克时，站立血压平均降低约27/17毫米汞柱；甲基多巴每日750毫克和1500毫克时，站立血压平均降低约28/14毫米汞柱。阿替洛尔每日150毫克与甲基多巴每日750毫克联合治疗四周后，血压降低38/25毫米汞柱。两种剂量的甲基多巴之间未观察到差异。在降低卧位和站立位舒张压方面，阿替洛尔的低剂量优于甲基多巴的低剂量。这些研究结果表明，对于持续服用氯噻酮治疗的患者，单独添加阿替洛尔或甲基多巴，或阿替洛尔与甲基多巴联合使用，对中度高血压的治疗均有效。
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