小鼠中的辐射抗性T淋巴细胞：在器官中的分布、Thy-1抗原含量及辅助活性
Radioresistant T lymphocytes in mice: distribution in organs, Thy-1 antigen content and helper activity.
作者信息
Yarilin A A, Polushkina E T, Anokhin Y N
出版信息
Immunology. 1980 Aug;40(4):565-9.
Radioresistant T lymphocytes (RRTL) were derived from spleens of CBA mice after gamma-irradiation (2000 rad). RRTL comprise 2.2-3.5% of the total T-cell population. Adult thymectomy and treatment with ATS or cortisol do not affect the yield of RRTL. The Thy-1 antigen content on RRTL surfaces exceeds that on thymocytes and splenic T lymphocytes. 51Cr-labelled RRTL fail to home into lymph nodes: a considerable number of labelled RRTL persist in the blood. In an adoptive transfer system RRTL display poor helper activity. The adoptive response of normal B cells plus RRTL was reduced when RRTL donors were preimmunized with the same antigen. It is not clear if the unusual properties of RRTL were induced by irradiation or if they pre-existed.
辐射抗性T淋巴细胞（RRTL）源自经γ射线照射（2000拉德）的CBA小鼠脾脏。RRTL占总T细胞群体的2.2 - 3.5%。成年小鼠胸腺切除以及用抗胸腺细胞血清（ATS）或皮质醇处理并不影响RRTL的产量。RRTL表面的Thy - 1抗原含量超过胸腺细胞和脾T淋巴细胞表面的含量。用51铬标记的RRTL无法归巢至淋巴结：相当数量的标记RRTL持续存在于血液中。在过继转移系统中，RRTL表现出较弱的辅助活性。当RRTL供体用相同抗原进行预免疫时，正常B细胞加RRTL的过继反应降低。目前尚不清楚RRTL的这些异常特性是由辐射诱导产生的，还是原本就存在。
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