Kirillova E N, Muksinova K N, Skukovskaia T L
Kosm Biol Aviakosm Med. 1988 Mar-Apr;22(2):62-5.
Changes in the content and function of cell populations and subpopulations involved in the humoral response of mice to the thymus-dependent antigen were investigated. The effect was followed during a prolonged continuous exposure to 137Cs gamma-emitter (total dose--5 Gy and daily dose--12 cGy for 22 hours) and after its termination. The data obtained give evidence for a decrease of the pool of polypotent lymphocyte precursors (CFUs), stable moderate hypoplasia of central and peripheral organs of the immune system, distinct inhibition of antibody production at the expense of reduced activity of precursors of lymphocytes, B-lymphocytes and T-helpers. In the remote postirradiation period residual radiation damage was seen in polypotent and committed precursors of lymphocytes and T-helpers which was responsible for the trend towards the decline of antibody production, hypoplasia in the spleen and lymph nodes being persistent.
研究了参与小鼠对胸腺依赖性抗原体液反应的细胞群体和亚群的含量及功能变化。在长时间持续暴露于137Csγ射线源（总剂量 - 5 Gy，每日剂量 - 12 cGy，持续22小时）期间及其结束后，观察了这种效应。所获得的数据表明，多能淋巴细胞前体（CFUs）池减少，免疫系统的中枢和外周器官出现稳定的中度发育不全，以淋巴细胞、B淋巴细胞和T辅助细胞前体活性降低为代价，抗体产生受到明显抑制。在照射后的远期，多能和定向的淋巴细胞及T辅助细胞前体出现残留辐射损伤，这是抗体产生呈下降趋势的原因，脾脏和淋巴结的发育不全持续存在。
