Montanaro D, Antonello A, Baggio B, Finotti P, Melacini P, Ferrari M
Int J Clin Pharmacol Ther Toxicol. 1980 Jul;18(7):322-3.
The effects of digoxin have been studied on PRA of 11 hypertensive patients treated with a single oral administration of the glycoside or submitted to a prolonged treatment. The experiments performed with a single oral administration (0,5 mg) showed that digoxin induces a significant decrease of the hyperreninemic response induced by furosemide. This effect of digoxin develops very quickly and is well evident when plasma levels of the glycoside are still low. However, in the patients pretreated with a beta blocker, digoxin was completely ineffective in preventing the response to furosemide. In view of the results, the hypothesis is put forward that digoxin mainly acts at renal level through an antiadrenergic activity.
研究了地高辛对11例高血压患者肾素活性（PRA）的影响，这些患者接受了单次口服该糖苷或长期治疗。单次口服（0.5毫克）地高辛的实验表明，地高辛可显著降低呋塞米诱导的高肾素反应。地高辛的这种作用起效非常快，当糖苷的血浆水平仍然很低时就很明显。然而，在预先使用β受体阻滞剂治疗的患者中，地高辛在预防对呋塞米的反应方面完全无效。鉴于这些结果，提出了地高辛主要通过抗肾上腺素能活性在肾脏水平发挥作用的假说。
