De Lima J, Caillens H, Beaufils M, Ardaillou R
Clin Nephrol. 1981 May;15(5):246-51.
Plasma antidiuretic hormone (ADH) was measured before and after furosemide administration in hypertensive patients (essential benign hypertensions with low plasma renin activity) and in normal subjects. Furosemide-induced reduction of plasma volume was about 10% after 2 hours. In normal subjects, plasma ADH rose progressively till the end of the study (1.5 pg/ml per hour corresponding to about 3 pg/ml per liter of plasma water lost) whereas it remained unchanged in hypertensive patients. There was an early increase of plasma renin activity (PRA) in normal subjects followed by a progressive fall. PRA response was blunted in hypertensive patients. These results show that volume-dependent ADH secretion is inhibited in patients with essential benign hypertension.
在高血压患者（原发性良性高血压且血浆肾素活性低）和正常受试者中，于给予呋塞米前后测量血浆抗利尿激素（ADH）。2小时后，呋塞米引起的血浆容量减少约为10%。在正常受试者中，血浆ADH逐渐上升直至研究结束（每小时上升1.5 pg/ml，相当于每丢失1升血浆水约上升3 pg/ml），而在高血压患者中其保持不变。正常受试者血浆肾素活性（PRA）早期升高，随后逐渐下降。高血压患者的PRA反应减弱。这些结果表明，原发性良性高血压患者中容量依赖性ADH分泌受到抑制。
