[芬太尼、氟哌利多和地西泮对离体人子宫肌层收缩功能的作用]
[Action of fentanyl, droperidol and diazepam on the contractile function of the isolated human myometrium].
作者信息
Kudrin A N, Koroza G S, Gersamiia T V
出版信息
Farmakol Toksikol. 1978 Sep-Oct;41(5):548-52.
The action of the analgesic phenthanyl, neuroleptic-droperidol and tranquilizer--diazepam on the contractile function of an isolated human myometrium was investigated. Phenthanyl (5.10(-8)--5.10(-7) g/ml) produced a stimulating influence on the contractility of an isolated human myometruim. When in relatively low concentrations (5.10(-7)--2.10(-6) g/ml) droperidol caused a stimulating effect and in higher concentrations (8.10(-6)--2.10(-5) g/ml) it exerted a biphasic action on the contractile function of an isolated myometrium, viz. first stimulation and then--inhibition. Diazepam (1.10(-12))--5.10(-8) g/ml suppressed the spontaneous periodic activity of an isolated human myometrium.
研究了镇痛药芬太尼、神经安定药氟哌利多和镇静剂地西泮对离体人子宫肌层收缩功能的作用。芬太尼（5×10⁻⁸～5×10⁻⁷克/毫升）对离体人子宫肌层的收缩性产生刺激作用。当氟哌利多处于相对低浓度（5×10⁻⁷～2×10⁻⁶克/毫升）时引起刺激效应，而在较高浓度（8×10⁻⁶～2×10⁻⁵克/毫升）时，它对离体子宫肌层的收缩功能发挥双相作用，即先是刺激，然后是抑制。地西泮（1×10⁻¹²～5×10⁻⁸克/毫升）抑制离体人子宫肌层的自发性周期性活动。
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