Piccolella E, Lombardi G, Morelli R
J Immunol. 1980 Nov;125(5):2082-8.
Purified human T and B lymphocytes were tested for their ability to show a mitogenic response to a purified polysaccharide (MPPS) extracted from C. albicans. It was found that neither T nor B cells alone could respond to MPPS. When a mixture of these two types of cells was tested, a normal response (comparable to the one of unfractionated peripheral blood lymphocytes) was observed. This response was not affected by prior depletion of macrophages. Results obtained with normal B or T cells mixed with mitomycin C-treated T or B cells indicated that a reciprocal helper effect exists between these two types of cells in their response to MPPS. This response could be inhibited by antisera against HL-A and Ia-like antigens.
对纯化的人T淋巴细胞和B淋巴细胞进行检测，以观察它们对从白色念珠菌中提取的纯化多糖（MPPS）产生促有丝分裂反应的能力。结果发现，单独的T细胞和B细胞都不能对MPPS作出反应。当检测这两种细胞的混合物时，观察到正常反应（与未分离的外周血淋巴细胞的反应相当）。这种反应不受预先去除巨噬细胞的影响。用正常B细胞或T细胞与丝裂霉素C处理过的T细胞或B细胞混合得到的结果表明，这两种细胞在对MPPS的反应中存在相互辅助作用。这种反应可被抗HL-A和Ia样抗原的抗血清所抑制。
