Kuhara T, Fujiwara M, Sudo K, Suzuki K, Kawamura A
Lab Anim. 1980 Apr;14(2):167-72. doi: 10.1258/002367780780942746.
No significant differences were observed between nude mice (nu/nu) born of homozygous (nu/nu) parents and those born of heterozygous (nu/+) mothers in the percentage of Thy-1-positive cells or immunoglobulin (Ig)-bearing cells in the spleen as assessed by immunofluorescence. There were no significant differences in the antibody response to thymus-dependent antigen or in the number of background plaque-forming cells to this antigen. The antibody response to thymus-independent antigen was not imparied at all in mice born from homozygous parents as compared with other nude mice or euthymic mice. It was concluded that the Thy-1-bearing (T) cells observed in nu/nu mice and the capacity of these mice to respond to thymus-dependent antigens arose independently of maternal T cells and of the influence of the maternal thymus.
通过免疫荧光评估发现，纯合子（nu/nu）亲本所生裸鼠（nu/nu）与杂合子（nu/+）母亲所生裸鼠脾脏中Thy-1阳性细胞或免疫球蛋白（Ig）携带细胞的百分比无显著差异。对胸腺依赖性抗原的抗体反应或该抗原的背景空斑形成细胞数量也无显著差异。与其他裸鼠或正常胸腺小鼠相比，纯合子亲本所生小鼠对胸腺非依赖性抗原的抗体反应完全没有受损。得出的结论是，在nu/nu小鼠中观察到的携带Thy-1的（T）细胞以及这些小鼠对胸腺依赖性抗原的反应能力独立于母源T细胞和母源胸腺的影响而产生。
