Kramer M H, Gershwin M E
Transplantation. 1976 Dec;22(6):539-44. doi: 10.1097/00007890-197612000-00001.
The immune competency of nude mice born from matings of strictly homozygous nu/nu X nu/nu parents was compared to nude mice derived from the breeding of either heterozygous nu/+ mothers by nu/nu fathers or nu/nu mothers by nu/+ fathers. Spleen cells from nude mice born from heterozygous mothers had significantly higher levels of beta-bearing cells than mice born from homozygous mothers and were minimally stimulated by the T cell mitogens Con A and PHA-P. In contrast, there were no detectable maternal influences when survival of skin allografts and primary sheep red cell stimulation were studied. Homing studies of 51Cr thymocytes in term-pregnant nude mice suggest that the enhanced T cell characteristics of nude mice born of nu/+ mothers are caused in part by placental transfer of allogeneic maternal lymphocytes.
将纯合子nu/nu与nu/nu亲本交配所生裸鼠的免疫能力，与由杂合子nu/+母鼠与nu/nu公鼠或nu/nu母鼠与nu/+公鼠交配所生裸鼠的免疫能力进行了比较。杂合子母鼠所生裸鼠的脾细胞中，含β细胞的水平显著高于纯合子母鼠所生的小鼠，并且对T细胞有丝分裂原刀豆球蛋白A（Con A）和植物血凝素-P（PHA-P）的刺激反应极小。相比之下，在研究皮肤同种异体移植的存活情况和对原发性绵羊红细胞的刺激反应时，未检测到母体影响。对足月妊娠裸鼠中51Cr标记胸腺细胞的归巢研究表明，nu/+母鼠所生裸鼠T细胞特征增强，部分原因是同种异体母体淋巴细胞通过胎盘转移所致。
