Azykbekov R
Vopr Onkol. 1980;26(10):41-4.
One hundred and fourty seven lymph nodes involved by metastases of the stomach, breast and lung cancer have been examined. It was found that in metastatic stomach cancer the PAS-reaction intensity is high, the mitotic level is low, the modal class of cells on the histogram is diploid. Breast cancer metastases are characterized by weak PAS-reaction, distinct stroma and cell reaction around the tumor, the prevalence of tetroploid nuclei on the histogram. In lung cancer metastases the PAS-positive substances are practically absent, the stroma and cell-reaction around the tumor is less distinct, the mitotic level is high, the number of hypodiploid nuclei on the histogram is 10.4%. Based on the data obtained histographically the author suggests a new criterion -- a coefficient of stability/a ratio of the diploid nuclei number to the number of the rest ones/ which allows a quantitative characterization of the intensity of the nuclei polymorphism in tumors.
对147个发生胃癌、乳腺癌和肺癌转移的淋巴结进行了检查。结果发现,转移性胃癌中PAS反应强度高,有丝分裂水平低,直方图上细胞的众数类为二倍体。乳腺癌转移的特点是PAS反应弱,肿瘤周围有明显的间质和细胞反应,直方图上四倍体核占优势。肺癌转移中几乎没有PAS阳性物质,肿瘤周围的间质和细胞反应不太明显,有丝分裂水平高,直方图上亚二倍体核的数量为10.4%。根据组织学获得的数据,作者提出了一个新的标准——稳定性系数/二倍体核数与其他核数的比值/,它可以对肿瘤细胞核多态性的强度进行定量表征。