[Value of the hormonal metabolic regulations in ischemic heart disease with respect to primary prophylaxis].

The value of hormonal-metabolic regulations is not yet to be actually estimated for the ischaemic heart disease and the acute myocardial infarction in contrast to the haemodynmic and electrocardiographic data. Metabolic risk factors may favourably be influenced by preventive measures, such as physical training and nutrition, even though details of the multilayered pathogenetic mechanism still need clarification. For the relations between hormones and cardiovascular diseases the hormonal regulation interests among the load examinations in such a way as the molecular aspects of the hormonal effects. Methodically there exist still many problems concerning the generalizing evidence of the two functional areas. At cellular level the thyroid hormones influence the activity of the enzymes of the oxidative metabolism, the synthesis of nucleic acid and protein and thus the contractility of the myocardium. Preventive measures, above all a nutrition with a diet rich in linoic acid, have provable effect on the hormone concentration and regulation possibly by influence on the cell membrane, which may not yet be estimated in their significance for the prevention of the disease of heart and circulation and which need further clarification.