Hilsted J
Acta Endocrinol Suppl (Copenh). 1980;238:139-44.
In order to elucidate the physiological significance of autonomic neuropathy in juvenile diabetics, cardiovascular, hormonal and metabolic functions have been investigated in three groups of juvenile diabetics: One group had no signs of neuropathy, one group had presumably slight autonomic neuropathy (reduced beat-to-beat variation in heart rate during hyperventilation) and one group had clinically severe autonomic neuropathy, defined by presence of orthostatic hypotension. In all three experimental situations we found sympathetic dysfunction causing cardiovascular and/or hormonal maladjustments in patients with autonomic neuropathy. Regarding metabolic functions we found normal responses to graded exercise and insulin-induced hypoglycemia in patients with autonomic neuropathy in spite of blunted catecholamine responses, suggesting increased sensitivity of glycogen stores and adipose tissue towards the action of catecholamine in patients with autonomic neuropathy.
为了阐明青少年糖尿病患者自主神经病变的生理意义，我们对三组青少年糖尿病患者的心血管、激素和代谢功能进行了研究：一组没有神经病变的迹象，一组可能有轻微的自主神经病变（过度通气时心率逐搏变化减少），另一组有临床严重的自主神经病变，由体位性低血压确定。在所有三种实验情况下，我们发现自主神经病变患者存在交感神经功能障碍，导致心血管和/或激素调节异常。关于代谢功能，我们发现自主神经病变患者对分级运动和胰岛素诱导的低血糖有正常反应，尽管儿茶酚胺反应减弱，这表明自主神经病变患者的糖原储备和脂肪组织对儿茶酚胺作用的敏感性增加。
