Hällgren R, Lundin L, Roxin L E, Venge P
Acta Med Scand. 1980;208(1-2):33-9. doi: 10.1111/j.0954-6820.1980.tb01146.x.
The serum levels of myoglobin were measured in 106 male alcoholics. Subnormal levels were found in 31% of the alcoholics with no alcohol consumption for the last 2--4 weeks, while none of them had elevated levels. Of the alcoholics on ambulatory control and with varying current alcohol intake. 18% had increased levels compared to healthy controls. Serial myoglobin levels were determined in 19 patients following the cessation of heavy drinking sprees. Despite the fact that none of the patients had clinical evidence of acute myopathy, marked myoglobin elevations were noted in five patients; their serum levels gradually declined and normalized with 4--7 days. Comparing the three groups, similar frequencies of subnormal or elevated serum CK levels were observed. Myoglobin levels were not raised due to impaired glomerular filtration rates. No correlation was found between serum myoglobin and laboratory signs of liver affection. Although hypophosphatemia, hypomagnesemia and hypokalemia were occasionally noted, decreased serum electrolytes did not have any relation to elevated serum myoglobin. A transient, slightly increased urinary excretion of myoglobin parallel with increased excretion of beta 2-microglobulin was observed in 2/17 alcoholics, suggesting that instances of myoglobinuria in alcoholics with heavy recent drinking may be due to a transient minor tubular dysfunction.
对106名男性酗酒者的血清肌红蛋白水平进行了测量。在过去2至4周内未饮酒的酗酒者中，31%的人肌红蛋白水平低于正常，且他们中无人水平升高。在门诊观察且当前饮酒量各异的酗酒者中，与健康对照组相比，18%的人肌红蛋白水平升高。对19名在停止狂饮后连续测定了肌红蛋白水平。尽管这些患者均无急性肌病的临床证据，但5名患者的肌红蛋白显著升高；其血清水平在4至7天内逐渐下降并恢复正常。比较这三组，观察到血清肌酸激酶水平低于正常或升高的频率相似。肌红蛋白水平升高并非由于肾小球滤过率受损。血清肌红蛋白与肝脏病变的实验室指标之间未发现相关性。尽管偶尔会出现低磷血症、低镁血症和低钾血症，但血清电解质降低与血清肌红蛋白升高并无关联。在17名酗酒者中有2名观察到肌红蛋白尿排泄短暂轻微增加，同时β2 -微球蛋白排泄增加，这表明近期大量饮酒的酗酒者出现肌红蛋白尿可能是由于短暂的轻微肾小管功能障碍。
