Weller P F, Ottesen E A, Heck L
Am J Trop Med Hyg. 1980 Sep;29(5):809-14. doi: 10.4269/ajtmh.1980.29.809.
In order to assess the immunodiagnostic utility of FST skin test antigen purified from Dirofilaria immitis, skin test responses were analyzed in 177 inhabitants of a South Pacific island hyperendemic for Wuchereria bancrofti filariasis. Although the distribution of immediate hypersensitivity skin test responses was similar to those found in other filarial endemic populations, individual immediate skin test reactions lacked the sensitivity and specificity to identify those with microfilaremia or those with any clinical or parasitologic evidence of filarial disease. Delayed hypersensitivity type skin test reactions were elicited by the antigen in 60% of people but again these delayed cutaneous reactions did not correlate with the presence or absence of stigmata of filariasis. These findings document the limitation of this antigen preparation in the immunodiagnosis of filariasis in residents of an endemic area.
为了评估从犬恶丝虫纯化的FST皮肤试验抗原的免疫诊断效用，对南太平洋一个班氏吴策线虫丝虫病高度流行岛屿的177名居民的皮肤试验反应进行了分析。虽然速发型超敏反应皮肤试验反应的分布与在其他丝虫病流行人群中发现的相似，但个体速发型皮肤试验反应缺乏识别有微丝蚴血症者或有丝虫病任何临床或寄生虫学证据者的敏感性和特异性。60%的人对抗原产生了迟发型超敏反应型皮肤试验反应，但同样，这些迟发型皮肤反应与丝虫病体征的有无无关。这些发现证明了这种抗原制剂在流行地区居民丝虫病免疫诊断中的局限性。
