Ishidate M, Yoshikawa K
Arch Toxicol Suppl. 1980;4:41-4. doi: 10.1007/978-3-642-67729-8_8.
Chromosome aberration tests (CH-test) in vitro were carried out on more than 400 chemicals from our environment, which included carcinogens and other compounds such as food additives, medical drugs, pesticides and those used in laboratories or industries. All results were compared with those obtained by mutation assays with bacteria (Ames test). Nearly half of these chemicals tested were positive either in the CH-tests or in the Ames tests. Among the chemicals being positive in the CH-tests, however, there were some which were negative in the Ames tests but have been proved to be carcinogenic in animals. Mammalian cell systems, therefore, may be not dispensable and are postulated for the primary screening for chemical mutagens and carcinogens in our environment.
对来自我们环境中的400多种化学物质进行了体外染色体畸变试验（CH试验），这些化学物质包括致癌物以及其他化合物，如食品添加剂、药物、农药以及实验室或工业中使用的物质。所有结果都与通过细菌突变试验（艾姆斯试验）获得的结果进行了比较。这些受试化学物质中近一半在CH试验或艾姆斯试验中呈阳性。然而，在CH试验中呈阳性的化学物质中，有一些在艾姆斯试验中呈阴性，但已被证明在动物中具有致癌性。因此，哺乳动物细胞系统可能并非可有可无，推测其可用于对我们环境中的化学诱变剂和致癌物进行初步筛选。
