单功能烷化剂5-(1-氮丙啶基)-2,4-二硝基苯甲酰胺（CB 1954）对核糖核苷酸还原酶的选择性抑制作用 - Suppr | 超能文献

Selective inhibition of ribonucleotide reductase by the monofunctional alkylating agent 5(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954).

作者信息

Tisdale M J, Habberfield A D

出版信息

Biochem Pharmacol. 1980 Oct 15;29(20):2845-53. doi: 10.1016/0006-2952(80)90021-0.

DOI:10.1016/0006-2952(80)90021-0

Abstract

摘要

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Selective inhibition of ribonucleotide reductase by the monofunctional alkylating agent 5(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954).单功能烷化剂5-(1-氮丙啶基)-2,4-二硝基苯甲酰胺（CB 1954）对核糖核苷酸还原酶的选择性抑制作用

Biochem Pharmacol. 1980 Oct 15;29(20):2845-53. doi: 10.1016/0006-2952(80)90021-0.

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CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells.

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A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells.

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The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).

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The toxicity and mutagenicity of the anti-tumour drug 5-aziridino-2,4-dinitrobenzamide (CB1954) is greatly reduced in a nitroreductase-deficient strain of E. coli.抗肿瘤药物5-氮丙啶基-2,4-二硝基苯甲酰胺（CB1954）在缺乏硝基还原酶的大肠杆菌菌株中，其毒性和致突变性大大降低。

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Studies on the mechanism of action of 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), a selective inhibitor of the Walker tumour.

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Synthesis and electron spin resonance study of spin-labelled compounds related to tumour-growth inhibitory nitroarylaziridines.与肿瘤生长抑制性硝基芳基氮丙啶相关的自旋标记化合物的合成与电子自旋共振研究。

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CB 1954 revisited. I. Disposition kinetics and metabolism.重访CB 1954。I. 处置动力学与代谢。

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