与肿瘤生长抑制性硝基芳基氮丙啶相关的自旋标记化合物的合成与电子自旋共振研究。
Synthesis and electron spin resonance study of spin-labelled compounds related to tumour-growth inhibitory nitroarylaziridines.
作者信息
Dodd N J, Harcus R G, Preston P N
出版信息
Z Naturforsch C Biosci. 1976 May-Jun;31(5-6):328-30. doi: 10.1515/znc-1976-5-621.
PMID:183409
Abstract
Three stable free radicals have been prepared which are akin to 5-aziridino-2,4-dinitrobenzamide (CB 1954); these compounds all contain a nitroxide function. The metabolism and excretion of two such compounds in mice has been monitored by electron spin resonance (ESR) spectroscopy and compared with that of the simpler nitroxide, 4-keto-2,2,6,6-tetramethylpiperidino-1-oxyl (tempone).
摘要
已经制备出三种与5-氮丙啶基-2,4-二硝基苯甲酰胺（CB 1954）类似的稳定自由基；这些化合物都含有一个氮氧化物官能团。通过电子自旋共振（ESR）光谱监测了两种此类化合物在小鼠体内的代谢和排泄情况，并与更简单的氮氧化物4-酮-2,2,6,6-四甲基哌啶-1-氧基（tempone）进行了比较。
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