Tessitore L, Messina M, Musi M, Aragno M, Baccino F M
Boll Soc Ital Biol Sper. 1980 Jan 15;56(1):22-6.
The weight of the liver and its DNA content definitely increase in rats transplanted with the ascites hepatoma AH-130 (Yoshida). The specific activity of cathepsin B1 decreases progressively in the liver during the first week after transplantation reaching one third of the initial levels, whereas that of cathepsin D shows the opposite behaviour increasing to levels 40% higher than in controls. The activity of the two proteinases in the blood plasma varies in a similar way, though the modifications are even more pronounced than in the liver. The relevance of the changes in tissue proteinase activities to the liver growth in tumour-bearing animals is discussed.
移植腹水型肝癌AH - 130（吉田氏）的大鼠，其肝脏重量及DNA含量肯定会增加。移植后第一周内，肝脏中组织蛋白酶B1的比活性逐渐下降，降至初始水平的三分之一，而组织蛋白酶D的比活性则表现出相反的变化，升高至比对照组高40%的水平。血浆中这两种蛋白酶的活性也有类似变化，不过其改变比肝脏中的更为明显。本文讨论了组织蛋白酶活性变化与荷瘤动物肝脏生长的相关性。
