用于口服镇痛药评估的非偏头痛性头痛
Non-migrainous headache for the evaluation of oral analgesics.
作者信息
von Graffenried B, Nüesch E
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):225S-231S. doi: 10.1111/j.1365-2125.1980.tb01804.x.
Abstract
1 Eight double-blind, randomized, placebo-controlled, single-dose, cross-over studies were carried out to evaluate the usefulness of testing the acute analgesic effect of drugs in out-patients with non-migrainous headache. 2 The reference compounds were either (1) aspirin, (2) a combination of aminopyrine, caffeine and butalbarbital (Optalidon), and (3) a combination of (2) with dihydroergotamine (Tonopan). 3 The test compounds were (1) proquazone, (2) fluproquazone and (3) and (4), new formulations of Optalidon and Tonopan in which the aminopyrine was replaced by propyphenazone. They were all found to be active. 4 A significant, dose-response relationship was established for aspirin (250, 500 and 1000 mg). 5 It is concluded that the non-migrainous headache model is a practical, reproducible and sensitive method for the investigation of the acute efficacy of analgesics.
摘要
- 开展了8项双盲、随机、安慰剂对照、单剂量、交叉研究，以评估在非偏头痛性头痛门诊患者中测试药物急性镇痛效果的实用性。2. 参比化合物为：（1）阿司匹林；（2）氨基比林、咖啡因和布他比妥的组合（奥普他酮）；（3）（2）与双氢麦角胺的组合（托诺潘）。3. 受试化合物为：（1）丙氧苯宗；（2）氟丙氧苯宗；（3）和（4）奥普他酮和托诺潘的新剂型，其中氨基比林被异丙安替比林取代。结果发现它们均有活性。4. 阿司匹林（250、500和1000毫克）呈现出显著的剂量 - 反应关系。5. 结论是，非偏头痛性头痛模型是一种用于研究镇痛药急性疗效的实用、可重复且敏感的方法。
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