Chou S M, Payne W N, Gibbs C J, Gajdusek D C
Brain. 1980 Dec;103(4):885-904. doi: 10.1093/brain/103.4.885.
Brains from three human cases of Creutzfeldt-Jakob disease and three monkey cases of transmitted Creutzfeldt-Jakob disease were examined. Spongiform change was present in all cases on both light and electron microscopic examination. Electron microscopic examination revealed membrane alterations within vacuoles in all cases. On SEM, both ulcerated and focally thickened membranes were apparent; TEM revealed splitting of unit membranes as well as focally thickened amorphous membranes. Small blisters with 70 to 150 nm particulates were seen on membranes in SEM. TEM revealed 10 nm electron-dense particles which might be either part of the infectious agent or a membrane alteration caused by it. The significance of these findings was discussed.
对三例人类克雅氏病病例和三例传播性克雅氏病猴病例的大脑进行了检查。在光学显微镜和电子显微镜检查中，所有病例均出现海绵状变化。电子显微镜检查显示，所有病例的空泡内均有膜改变。扫描电子显微镜显示，既有溃疡的膜，也有局部增厚的膜；透射电子显微镜显示单位膜分裂以及局部增厚的无定形膜。在扫描电子显微镜下，在膜上可见带有70至150纳米颗粒的小水泡。透射电子显微镜显示有10纳米的电子致密颗粒，它们可能是感染因子的一部分，或者是由其引起的膜改变。讨论了这些发现的意义。
