Erickson A D
Cancer Res. 1980 Oct;40(10):3598-3601.
Thirty patients with lung cancer were studied using the leukocyte migration-inhibition assay. Cryostat sections of autologous and homologous carcinoma tissues and normal lung were used as antigens. Although no inhibition of migration was seen using autologous cancer tissues, seven of 30 patients (23%) demonstrated inhibition of leukocyte migration in response to homologous cancer sections. No association with clinical stage was appreciated. Seven patients demonstrated enhanced migration to homologous malignant tissues; six of these are still alive more than 18 months after testing. The extent of lymphocytic infiltration of tumors was estimated as a possible reflection of host immune response or tumor antigenicity. Patients whose tumors were prominently infiltrated by lymphocytes had a significantly better prognosis than did those whose tumors showed lesser degrees of infiltration. The degree to which a tumor is infiltrated by the host's lymphocytes appears to correlate with survival. Whether or not this correlation is independent of tumor cell type remains to be determined.
采用白细胞游走抑制试验对30例肺癌患者进行了研究。自体和同种癌组织以及正常肺组织的低温切片用作抗原。虽然使用自体癌组织未观察到游走抑制，但30例患者中有7例（23%）对同种癌切片表现出白细胞游走抑制。未发现与临床分期相关。7例患者表现出向同种恶性组织的游走增强；其中6例在检测后存活超过18个月。肿瘤的淋巴细胞浸润程度被评估为宿主免疫反应或肿瘤抗原性的可能反映。肿瘤被淋巴细胞显著浸润的患者预后明显好于肿瘤浸润程度较轻的患者。肿瘤被宿主淋巴细胞浸润的程度似乎与生存率相关。这种相关性是否独立于肿瘤细胞类型仍有待确定。
