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Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase.

作者信息

Feinberg A, Zedeck M S

出版信息

Cancer Res. 1980 Dec;40(12):4446-50.

PMID:7002292
Abstract
摘要

相似文献

1
Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase.酒精脱氢酶将有机特异性致癌物甲基偶氮甲醇转化为高反应活性烷基化剂的过程。
Cancer Res. 1980 Dec;40(12):4446-50.
2
Organ-specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases.致癌物甲基偶氮甲醇与烟酰胺腺嘌呤二核苷酸依赖性脱氢酶代谢相关的器官特异性效应。
Cancer Res. 1977 Nov;37(11):4182-9.
3
Histochemical findings suggesting that methylazoxymethanol, a liver and kidney carcinogen, is a substrate for hepatic and renal choline dehydrogenase.
Carcinogenesis. 1981;2(11):1135-9. doi: 10.1093/carcin/2.11.1135.
4
Inhibition of methylazoxymethanol-induced intestinal tumors in the rat by pyrazole with paradoxical effects on skin and kidney.吡唑对大鼠甲基偶氮甲醇诱导的肠道肿瘤具有抑制作用，但对皮肤和肾脏却产生了矛盾的影响。
Cancer Res. 1982 May;42(5):1774-80.
5
Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.4-碘吡唑和3-甲基吡唑对大鼠肝脏和大鼠结肠黏膜在体内将甲基偶氮甲醇代谢活化为DNA甲基化物质的不同作用。
J Cancer Res Clin Oncol. 1987;113(2):145-50. doi: 10.1007/BF00391436.
6
Non-alcohol dehydrogenase-mediated metabolism of methylazoxymethanol in the deer mouse, Peromyscus maniculatus.
Cancer Res. 1984 Jul;44(7):2885-91.
7
Differential susceptibility of rat and guinea pig colon mucosa DNA to methylation by methylazoxymethyl acetate in vivo.大鼠和豚鼠结肠黏膜DNA在体内对乙酸甲基氧化偶氮甲酯甲基化的敏感性差异。
Cancer Lett. 1985 Dec;29(3):293-300. doi: 10.1016/0304-3835(85)90140-5.
8
Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole.
Cancer Res. 1978 Dec;38(12):4515-21.
9
Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.乙酸甲基偶氮甲醇在F344大鼠和2系豚鼠体内的代谢及其受吡唑和双硫仑的抑制作用。
J Cancer Res Clin Oncol. 1984;108(1):129-34. doi: 10.1007/BF00390984.
10
Modeling the metabolic pathways of methylazoxymethanol: a semiempirical molecular orbital study.甲基偶氮甲醇代谢途径的建模：一项半经验分子轨道研究。
Cancer Biochem Biophys. 1981;5(2):119-24.

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