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Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole.

作者信息

Fiala E S, Kulakis C, Christiansen G, Weisburger J H

出版信息

Cancer Res. 1978 Dec;38(12):4515-21.

PMID:719636
Abstract
摘要

相似文献

1
Inhibition of the metabolism of the colon carcinogen, azoxymethane, by pyrazole.
Cancer Res. 1978 Dec;38(12):4515-21.
2
Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: similarity to the microsomal metabolism of N-nitrosodimethylamine.长期给予乙醇可增强大鼠肝微粒体将偶氮甲烷代谢为甲基偶氮甲醇的能力：与N-亚硝基二甲胺的微粒体代谢相似。
Cancer Res. 1987 Jun 15;47(12):3123-9.
3
Effects of timing and quantity of chronic dietary ethanol consumption on azoxymethane-induced colonic carcinogenesis and azoxymethane metabolism in Fischer 344 rats.长期饮食中乙醇摄入的时间和量对Fischer 344大鼠中由氧化偶氮甲烷诱导的结肠癌发生及氧化偶氮甲烷代谢的影响。
Cancer Res. 1987 Aug 15;47(16):4305-11.
4
Organ-specific effects of the carcinogen methylazoxymethanol related to metabolism by nicotinamide adenine dinucleotide-dependent dehydrogenases.致癌物甲基偶氮甲醇与烟酰胺腺嘌呤二核苷酸依赖性脱氢酶代谢相关的器官特异性效应。
Cancer Res. 1977 Nov;37(11):4182-9.
5
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.大鼠肝微粒体介导的偶氮甲烷N-去甲基化及致突变性
Cancer Res. 1978 Dec;38(12):4585-90.
6
Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.乙酸甲基偶氮甲醇在F344大鼠和2系豚鼠体内的代谢及其受吡唑和双硫仑的抑制作用。
J Cancer Res Clin Oncol. 1984;108(1):129-34. doi: 10.1007/BF00390984.
7
Inhibition of methylazoxymethanol-induced intestinal tumors in the rat by pyrazole with paradoxical effects on skin and kidney.吡唑对大鼠甲基偶氮甲醇诱导的肠道肿瘤具有抑制作用，但对皮肤和肾脏却产生了矛盾的影响。
Cancer Res. 1982 May;42(5):1774-80.
8
Age-related changes in biotransformation of azoxymethane and methylazoxymethanol in vitro.
Xenobiotica. 1990 May;20(5):501-13. doi: 10.3109/00498259009046865.
9
Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.4-碘吡唑和3-甲基吡唑对大鼠肝脏和大鼠结肠黏膜在体内将甲基偶氮甲醇代谢活化为DNA甲基化物质的不同作用。
J Cancer Res Clin Oncol. 1987;113(2):145-50. doi: 10.1007/BF00391436.
10
Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane.对结肠致癌物1,2 - 二甲基肼和氧化偶氮甲烷的代谢及作用方式的研究。
Cancer. 1977 Nov;40(5 Suppl):2436-45. doi: 10.1002/1097-0142(197711)40:5+<2436::aid-cncr2820400908>3.0.co;2-u.

引用本文的文献

1
Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate.用氧化偶氮甲烷以及氧化偶氮甲烷与葡聚糖硫酸钠处理后野生型和免疫受损小鼠的结肠癌发生情况
Mol Carcinog. 2016 Jul;55(7):1187-95. doi: 10.1002/mc.22361. Epub 2015 Jul 8.
2
Protection against 1,2-di-methylhydrazine-induced systemic oxidative stress and altered brain neurotransmitter status by probiotic Escherichia coli CFR 16 secreting pyrroloquinoline quinone.分泌吡咯喹啉醌的益生菌大肠杆菌CFR 16对1,2 - 二甲基肼诱导的全身氧化应激和脑内神经递质状态改变的保护作用。
Curr Microbiol. 2015 May;70(5):690-7. doi: 10.1007/s00284-014-0763-9. Epub 2015 Jan 14.
3
Mouse models of colorectal cancer.
结直肠癌的小鼠模型
Chin J Cancer. 2011 Jul;30(7):450-62. doi: 10.5732/cjc.011.10041.
4
Mouse models for the study of colon carcinogenesis.用于研究结肠癌发生的小鼠模型。
Carcinogenesis. 2009 Feb;30(2):183-96. doi: 10.1093/carcin/bgn267. Epub 2008 Nov 26.
5
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.黄嘌呤氧化酶抑制剂乙酸1'-乙酰氧基胡椒酚酯对氧化偶氮甲烷诱导的大鼠结肠癌发生的化学预防作用
Jpn J Cancer Res. 1997 Sep;88(9):821-30. doi: 10.1111/j.1349-7006.1997.tb00457.x.
6
Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.乙酸甲基偶氮甲醇在F344大鼠和2系豚鼠体内的代谢及其受吡唑和双硫仑的抑制作用。
J Cancer Res Clin Oncol. 1984;108(1):129-34. doi: 10.1007/BF00390984.
7
Metabolism and activation of chemical carcinogens.化学致癌物的代谢与活化
Mol Cell Biochem. 1980 Sep 15;32(2):95-104. doi: 10.1007/BF00227802.
8
Modifying effects of fungal and herb metabolites on azoxymethane-induced intestinal carcinogenesis in rats.真菌和草本植物代谢产物对大鼠偶氮甲烷诱导的肠道癌变的修饰作用。
Jpn J Cancer Res. 1992 Dec;83(12):1273-8. doi: 10.1111/j.1349-7006.1992.tb02758.x.
9
Dietary fat and colon cancer: animal model studies.膳食脂肪与结肠癌：动物模型研究
Lipids. 1992 Oct;27(10):807-13. doi: 10.1007/BF02535855.