Gaffney B J, Wasserman A G, Rotsztain A, Rios J C
Cardiovasc Clin. 1980;11(1):7-25.
Sick sinus syndrome has become a frequent and challenging diagnosis for the practicing physician (Fig. 6). Increased longevity will create even more patients in need of effective therapy. Multiple etiologies have been described, but the common final pathway in most instances appears to be chronic fibrosis of the sinus node. The multifaceted features of the syndrome have delayed an organized diagnostic approach until recently. Noninvasive diagnosis often suffices, particularly with the availability of Holter monitoring. Invasive studies help to confirm sinus node dysfunction and possible associated conduction defects in these patients. The prognosis is variable and at times unpredictable. Nonetheless, it is best to establish the diagnosis promptly and to institute appropriate therapy. Cardiac pacing has had a particularly beneficial impact on the long-term management of the sick sinus syndrome.
病态窦房结综合征已成为执业医师经常面临且颇具挑战性的诊断难题（图6）。寿命延长将使更多患者需要有效的治疗。已描述了多种病因，但在大多数情况下，常见的最终途径似乎是窦房结的慢性纤维化。该综合征的多方面特征导致直到最近才形成有组织的诊断方法。非侵入性诊断通常就足够了，尤其是有动态心电图监测的情况下。侵入性研究有助于证实这些患者的窦房结功能障碍以及可能存在的相关传导缺陷。预后各不相同，有时难以预测。尽管如此，最好还是及时做出诊断并采取适当的治疗措施。心脏起搏对病态窦房结综合征的长期管理产生了特别有益的影响。
