The Persantine-aspirin reinfarction study. The Persantine-aspirin Reinfarction Study (PARIS) research group.

The efficacy and safety of a combination of Persantine and aspirin, of aspirin alone and of a placebo as a regimen for preventing reinfarction were compared in 2026 patients who had recovered from a documented acute myocardial infarction (MI) that had occurred 8 weeks to 5 years previously. Baseline variables were comparable, and almost all surviving patients were treated for 3 years. There was a trend toward improved survival rates both for the combination and single drug compared with placebo. Coronary incidence was significantly lower in the combination group compared with placebo at each 4-month interval during the first 24 months of treatment, whereas significant reductions in the aspirin group occurred only at 8 and 24 months. Gastric and renal side effects were more common in the treated groups. To confirm the above results and the findings that the group of patients enrolled within 6 months of last MI had the largest reduction in mortality in the combination group, another study has been designed to compare the combination with a placebo in a large group of patients.