Warren S E, Vieweg W V, O'Connor D T
Clin Cardiol. 1980 Oct;3(5):348-51. doi: 10.1002/clc.4960030410.
Sympathetic nervous system activity was studied in 38 patients with essential hypertension during high- and low-sodium diets. Salt restriction was associated with a modest (6 mmHg) decline in mean arterial pressure, while the urinary excretion of catecholamines, metanephrines, and vanillylmandelic acid increased significantly. Plasma renin activity also increased. It is concluded that short-term low-sodium diet therapy for essential hypertension results in only small decrements in mean arterial pressure and may be limited in hypotensive effect by activation of the sympathetic nervous system. Support is offered for the rationale of sympatholytic drug therapy as an initial step in the management of hypertensive patients requiring arterial pressure reductions greater than those afforded by diet alone.
对38例原发性高血压患者在高钠饮食和低钠饮食期间的交感神经系统活动进行了研究。限盐与平均动脉压适度下降（6 mmHg）相关，而儿茶酚胺、甲氧基肾上腺素和香草扁桃酸的尿排泄量显著增加。血浆肾素活性也增加。得出的结论是，原发性高血压的短期低钠饮食疗法仅导致平均动脉压小幅下降，并且可能因交感神经系统激活而使降压效果受限。对于需要降低动脉压且降幅大于单纯饮食所能提供的降幅的高血压患者，支持将交感神经阻滞药物治疗作为初始治疗步骤的理论依据。
