Lulling J, Delwiche J P, Prignot J
Eur J Respir Dis. 1980 Apr;61(2):108-12.
The speed of onset of the bronchodilating effect of ibuterol, a derivative of terbutaline, was measured by the method of air flow interruptions, which enables an almost continuous study of lung resistance before and after the administration of a bronchodilator. In the double-blind comparison between ibuterol and placebo, the onset of action of the new beta 2-agonist has been shown to take place within 30-45 sec. This indicates that ibuterol is a bronchodilator with rapid onset of action.
用气流阻断法测定了特布他林衍生物异丁特罗的支气管扩张作用起效速度，该方法能对支气管扩张剂给药前后的肺阻力进行几乎连续的研究。在异丁特罗与安慰剂的双盲比较中，已表明这种新型β2激动剂的起效时间在30 - 45秒内。这表明异丁特罗是一种起效迅速的支气管扩张剂。
