Hellström P E, Nordman C, Salonen T
Scand J Respir Dis. 1977 Oct;58(5):247-51.
The effect of equimolar doses of ibuterol, 0.75 mg, and terbutaline, 0.50 mg, was compared in 16 asthmatics. Both drugs were given double-blind in a single dose by inhalation. The drugs did not significantly differ from each other in any of the parameters used in the trial. Both had rapid onset of action on the bronchospasm as measured with a Wright's peak flow meter. The effect was still statistically significant 300 min after the inhalation compared with the pre-treatment values. Neither drug had any effect of clinical importance on heart rate or blood pressure. No side effects were observed during the trial.
在16名哮喘患者中比较了等摩尔剂量的异丁特罗（0.75毫克）和特布他林（0.50毫克）的效果。两种药物均通过吸入单剂量双盲给药。在试验中使用的任何参数方面，两种药物之间均无显著差异。使用赖特峰流速仪测量，两种药物对支气管痉挛均有快速起效作用。与治疗前值相比，吸入后300分钟效果仍具有统计学意义。两种药物对心率或血压均无具有临床重要性的影响。试验期间未观察到副作用。
