Baronti A, Grieco A, Vibelli C
Eur J Respir Dis. 1980 Jun;61(3):143-50.
Twenty-one patients with chronic bronchitis and reversible airway obstruction participated in two single-blind, cross-over, placebo-controlled studies in inhaled clenbuterol - a new bronchodilator - and salbutamol. Nine patients participated in a dose-response study. Clenbuterol 10 microgram/puff, salbutamol 100 microgram/puff and placebo, were given by pressurized aerosol in cumulative doses of 1, 2, 4, 8, and 16 inhalations of each drug and placebo. The mean peak % FEV1 increases above the baseline were similar after all doses of clenbuterol and salbutamol and were significantly greater than after placebo. No cardiovascular effects were observed. Tremors were noted in two patients after 160 microgram clenbuterol and in one patient after 1600 microgram salbutamol. In a second study, clenbuterol (20 microgram), salbutamol (200 microgram) - two equieffective doses - and placebo were compared in a 6 h period in 12 patients. Clenbuterol and salbutamol produced bronchodilation of comparable magnitude, onset of action (15 min) and duration (4-6 h). Clenbuterol is an effective bronchodilator and, on the basis of molecular weight, about ten times more potent than salbutamol when given by aerosol.
21例患有慢性支气管炎且气道具有可逆性阻塞的患者参与了两项关于吸入新型支气管扩张剂克仑特罗和沙丁胺醇的单盲、交叉、安慰剂对照研究。9例患者参与了剂量反应研究。通过压力定量气雾剂给予克仑特罗10微克/喷、沙丁胺醇100微克/喷和安慰剂，每种药物和安慰剂的累积剂量分别为1、2、4、8和16喷。所有剂量的克仑特罗和沙丁胺醇给药后，平均FEV1峰值较基线的增加相似，且显著大于安慰剂给药后。未观察到心血管效应。160微克克仑特罗给药后有2例患者出现震颤，1600微克沙丁胺醇给药后有1例患者出现震颤。在第二项研究中，对12例患者在6小时内比较了克仑特罗（20微克）、沙丁胺醇（200微克）——两个等效剂量——和安慰剂。克仑特罗和沙丁胺醇产生的支气管扩张程度相当，起效时间（15分钟）和持续时间（4 - 6小时）相似。克仑特罗是一种有效的支气管扩张剂，基于分子量，通过气雾剂给药时其效力约为沙丁胺醇的10倍。
