使用二甲基二十八烷基溴化铵作为佐剂时，不同小鼠品系中迟发型超敏反应的可变表达。
Variable expression of delayed hypersensitivity in different mouse strains using dimethyl dioctadecyl ammonium bromide as an adjuvant.
作者信息
Snippe H, Johannesen L, Lizzio E, Merchant B
出版信息
Immunology. 1980 Mar;39(3):399-405.
Delayed-type hypersensitivity measured as footpad swelling was studied in large number of inbred mouse strains. A conjugate of bovine serum albumin (BSA) with the small 2,4-dinitrophenyl (DNP) hapten served to generate strong reactions, specific for the DNP group. Delayed hypersensitivity was produced with the DNP-BSA complex mixed with the cationic, surface active lipid, dimethyl dioctadecyl ammonium bromide (DDA). Great variation was observed in delayed hypersensitivity among different mouse strains. For convenience, the mice were classified into five groups, notably: non-, low, moderate, good and high responders. The highest responding animals were BALB/cJ mice, the lowest were P/JN and outbred nu/nu mice. No correlation was observed between H-2 type and the intensity of the elicited reactions.
通过足垫肿胀测量的迟发型超敏反应在大量近交系小鼠品系中进行了研究。牛血清白蛋白（BSA）与小的2,4-二硝基苯基（DNP）半抗原的偶联物用于产生针对DNP基团的强烈反应。用与阳离子表面活性脂质二甲基二十八烷基溴化铵（DDA）混合的DNP-BSA复合物产生迟发型超敏反应。在不同小鼠品系之间观察到迟发型超敏反应有很大差异。为方便起见，将小鼠分为五组，即：无反应者、低反应者、中等反应者、良好反应者和高反应者。反应最高的动物是BALB/cJ小鼠，最低的是P/JN和远交系裸鼠。未观察到H-2类型与引发反应强度之间的相关性。
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