Pavelić K, Basić I, Pavelić J
J Cancer Res Clin Oncol. 1980;97(3):275-83. doi: 10.1007/BF00405779.
Hypoglycemia and hypoinsulinemia accompanied the i.m. growth of mammary aplastic carcinoma in CBA mice. In hosts rendered diabetic by means of alloxan, the tumor decreased blood glucose levels to almost the level seen in non-diabetic mice. Tumors maintained in diabetic mice grew faster after each subsequent transplantation into diabetic mice, and we noted increased incorporation of 3H-thymidine into DNA of these tumor cells. The observed proliferation enhancement of mammary aplastic carcinoma maintained in diabetic mice is caused by de novo insulin and glucagon synthesis, apparently by the tumor cells themselves.
低血糖和低胰岛素血症伴随CBA小鼠乳腺发育不全癌的肌肉内生长。在通过四氧嘧啶致糖尿病的宿主中，肿瘤将血糖水平降低至几乎与非糖尿病小鼠所见水平相同。在糖尿病小鼠中维持的肿瘤，每次随后移植到糖尿病小鼠体内后生长得更快，并且我们注意到这些肿瘤细胞的DNA中3H-胸腺嘧啶核苷的掺入增加。在糖尿病小鼠中维持的乳腺发育不全癌所观察到的增殖增强是由肿瘤细胞自身从头合成胰岛素和胰高血糖素引起的。
