Pavelić K
J Natl Cancer Inst. 1979 Jan;62(1):139-41.
Increased glucose levels in blood of diabetic and of normoinsulinemic hyperglycemic CBA/H mice were accompanied by suppressed growth of aplastic carcinoma. Tumors maintained in diabetic mice grew faster after each subsequent transplantation into diabetic mice, but those maintained in hyperglycemic normoinsulinemic mice grew at a constant rate. Evidence revealed that tumor growth was suppressed by hyperglycemia. The observed proliferation enhancement of aplastic carcinoma maintained in diabetic mice was caused by de novo insulin synthesis, probably by the tumor cells themselves.
糖尿病CBA/H小鼠以及正常胰岛素血症性高血糖CBA/H小鼠血液中葡萄糖水平升高，同时伴有再生障碍性癌生长受抑制。在糖尿病小鼠体内维持生长的肿瘤，每次后续移植到糖尿病小鼠体内后生长加快，但在高血糖正常胰岛素血症小鼠体内维持生长的肿瘤则以恒定速率生长。有证据表明，高血糖抑制肿瘤生长。观察到糖尿病小鼠体内维持生长的再生障碍性癌增殖增强是由肿瘤细胞自身重新合成胰岛素所致。
