Dixon A J, Burns J, Dunnill M S, McGee J O
J Clin Pathol. 1980 Nov;33(11):1021-8. doi: 10.1136/jcp.33.11.1021.
The distribution of fibronectin in 42 renal biopsies was investigated using an indirect immunoperoxidase technique on paraffin sections of formalin-fixed material. Biopsies were obtained from normal human kidneys and from patients with a variety of glomerular disorders. In normal glomeruli, fibronectin was present in Bowman's capsule, in the mesangium, and outlining peripheral capillary loops. A significant increase in fibronectin was observed in most types of glomerulopathy with a distribution closely related to the histopathological diagnosis. Fibronectin was diminished or absent in segmental scars, old diabetic nodules, and hyalinised glomeruli.
采用间接免疫过氧化物酶技术，对42例肾活检标本的福尔马林固定石蜡切片进行纤连蛋白分布研究。活检标本取自正常人类肾脏以及患有各种肾小球疾病的患者。在正常肾小球中，纤连蛋白存在于鲍曼囊、系膜以及外周毛细血管袢轮廓处。在大多数类型的肾小球病中观察到纤连蛋白显著增加，其分布与组织病理学诊断密切相关。在节段性瘢痕、陈旧性糖尿病结节和玻璃样变性肾小球中，纤连蛋白减少或缺失。
