Stenman S, Vaheri A
J Exp Med. 1978 Apr 1;147(4):1054-64. doi: 10.1084/jem.147.4.1054.
Fibronectin is a major surface-associated glycoprotein of cultured fibroblasts and it is also present in human plasma. Antiserum specific for human fibronectin was used to study the distribution of fibronectin in normal adult human tissues. The protein was detected (a) characteristically in various basement membranes including capillary walls: (b) around individual smooth muscle cells and in the sarcolemma of striated muscle fibers; and (c) in the stroma of lymphatic tissue and as thin fibers in loose connective tissue. The distribution of fibronectin was distinct from that of collagen and elastic fibers, but was very similar to reticulin, as demonstrated by conventional histological staining. The results indicate that fibronectin is a major component of connective tissue matrix. The distribution also indicates that most types of adherent cells abut fibronectin-containing structures. This supports the possible role of fibronectin in cell-cell and cell-matrix interactions in tissues.
纤连蛋白是培养的成纤维细胞的一种主要的表面相关糖蛋白，它也存在于人体血浆中。用针对人纤连蛋白的抗血清来研究纤连蛋白在正常成人组织中的分布。该蛋白在以下部位被检测到：(a) 典型地存在于包括毛细血管壁在内的各种基底膜中；(b) 在单个平滑肌细胞周围以及横纹肌纤维的肌膜中；(c) 在淋巴组织的基质中以及在疏松结缔组织中呈细纤维状。如传统组织学染色所示，纤连蛋白的分布与胶原蛋白和弹性纤维不同，但与网硬蛋白非常相似。结果表明纤连蛋白是结缔组织基质的主要成分。这种分布还表明大多数类型的贴壁细胞邻接含纤连蛋白的结构。这支持了纤连蛋白在组织中的细胞间和细胞-基质相互作用中可能发挥的作用。
