Sandhu S S, Waters M D
J Environ Sci Health B. 1980;15(6):929-48. doi: 10.1080/03601238009372223.
Over the last few decades, the use of chemical pesticides has increased dramatically in the U.S. This relatively sudden increase greatly concerns the U.S. Environmental Protection Agency (EPA), since it has the responsibility for ensuring the safety of all pesticides used in the U.S. In response to this concern, EPA has established a review program, the Rebuttable Presumption Against Registration (RPAR), for periodically reassessing the mutagenic and carcinogenic potential of pesticide compounds. This paper presents a review and evaluation of the data reported in the literature on six chemical pesticides suspect for mutagenic potential. The pesticide chemicals discussed are maleic hydrazide; rotenone; monuron; diallate; triallate, and benomyl.
在过去几十年里，美国化学农药的使用量急剧增加。这种相对突然的增长引起了美国环境保护局（EPA）的极大关注，因为该机构负责确保美国使用的所有农药的安全性。为回应这一关切，EPA制定了一项审查计划，即“可反驳的注册推定”（RPAR），用于定期重新评估农药化合物的致突变和致癌潜力。本文对文献中报道的六种具有潜在致突变性的化学农药的数据进行了综述和评估。所讨论的农药化学品有马来酰肼；鱼藤酮；灭草隆；燕麦敌；野麦畏和苯菌灵。
