Sell S, Gamboa D, Baker-Zander S A, Lukehart S A, Miller J N
J Invest Dermatol. 1980 Dec;75(6):470-5. doi: 10.1111/1523-1747.ep12524230.
Intradermal infection of rabbits with Treponema pallidum imitiates rapid and active cellular response at the site of injection. During the first 2 weeks following infection, there is a marked increase in the numbers of organisms at the site of infection. Systemic dissemination of treponemes occurs during the early stage of infection, presumably before the immune response is fully mobilized. The mononuclear infiltration, which is apparent at the lesion site one week postinfection, becomes more pronounced at 2 weeks. The infiltrating cells are predominantly T lymphocytes and macrophages. By 4 weeks postinfection, most of the organisms have been cleared from the primary site; however, low numbers of treponemes survive locally and in distant tissues. Thus, whereas infection with T. pallidum appears to activate immune mechanisms which are capable of clearing most of the organisms from the primary lesion, some organisms are able to evade these mechanisms and persist in vivo.
用梅毒螺旋体对家兔进行皮内感染，可在注射部位引发快速且活跃的细胞反应。在感染后的头两周内，感染部位的病原体数量显著增加。梅毒螺旋体在感染早期会发生全身播散，大概是在免疫反应完全动员起来之前。感染一周后在病变部位明显可见的单核细胞浸润，在两周时变得更加明显。浸润细胞主要是T淋巴细胞和巨噬细胞。感染四周后，大部分病原体已从原发部位清除；然而，仍有少量梅毒螺旋体在局部和远处组织中存活。因此，虽然梅毒螺旋体感染似乎激活了能够从原发病变清除大部分病原体的免疫机制，但一些病原体能够逃避这些机制并在体内持续存在。
